Preventron: Trontinemab in people at risk of developing Alzheimer’s disease

What is the aim of the study? 

The main aim of the PrevenTRON study is to find out if a new medicine called trontinemab can help stop or slow down the development of Alzheimer’s disease before it causes memory and thinking problems.

Here is what the study is testing: 

• Helping before symptoms start: The study focuses on adults who currently have no problems with their memory or thinking, but who have changes in their brain or blood that may be linked to Alzheimer's disease. For example, they may have a build-up of a protein called amyloid, which can increase the chance of developing Alzheimer's disease in the future. 
• Testing a new way to reach the brain: Trontinemab is designed to find amyloid in the brain and help remove it. Getting medicines into the brain can be difficult because the brain has a protective barrier that blocks many medicines. Trontinemab uses a special method called 'Brainshuttle' to help the medicine cross this barrier and reach the brain.
• Comparing treatments: Some people in the study will get trontinemab, while others will get a placebo (a treatment that looks the same but has no medicine in it). Researchers will compare the groups over several years to see if the medicine helps keep people's brains healthy for longer.

In short, the study aims to prove whether treating the root causes of Alzheimer's disease before memory loss appears an effective way to stop or slow the disease. 

What will you be asked to do during the study? 

• Eligibility Screening (Up to 10 weeks): Complete basic health checks, blood tests, brain scans and memory questionnaires to see if you can join the study.
• Treatment Schedule (4 to 6 years): Receive monthly intravenous (IV) infusions of either the study drug or a placebo for the first 6 months, followed by maintenance infusions once every 6 months thereafter. 
• Safety & Memory Tracking: Complete interactive memory tests on a tablet and undergo safety brain MRI scans roughly every 6 months. 
• Observations & Pre-Medications: Take standard pre-medications (paracetamol and a steroid) to prevent side effects before each infusion, then stay at the clinic for 1 to 2 hours of observation. 
• Mandatory Study Partner: Bring a close friend or family member to appointments who can answer brief questionnaires about your day-to-day routine.